Peptide Pulse + AMA

Overview

In Episode 4 of the podcast, Dr. Seeds provides an in-depth exploration of transformative peptides for 2024, particularly focusing on GLP1 receptor agonists and their profound effects on various bodily systems. He discusses the evolution of these therapies, highlighting advancements from single peptides to more effective combinations, and explains the significance of natural growth hormone secretagogues like Tesmorelin versus synthetic alternatives. The episode further delves into the neuropeptide Semax and its implications for stress management and mitochondrial function, emphasizing the importance of peptide modulation in maintaining cellular balance. Listeners are encouraged to engage in an "Ask Me Anything" segment, addressing queries about peptide research, athletic recovery, and the role of AI in developing targeted therapies. The session concludes with a preview of the next episode, featuring expert insights on health and mindset.

Notes

Introduction to Peptide Pulse(00:00 - 14:36)

• Episode focuses on reviewing the most life-changing peptides of 2024
• GLP1 receptor agonists highlighted as having a historical explosion in public interest
• Dr. Seeds notes he's been educating about GLP1s and their relevance to cellular metabolism for over 10 years
• GLP1s influence multiple body areas including brain, muscle, bone, kidney, liver, and pancreas
• Dr. Seeds predicted GLP1s would change medicine and health over a decade ago
• Evolution of GLP1s discussed: from single peptide (Ozempic) to combinations with GIP (Mounjaro/tirzepatide) and glucagon (retatrutide)
• Each iteration improves efficiency and patient tolerance (decreased nausea and fatigue)
• Discussion about compounding pharmacies providing peptides more affordably than insurance coverage

Deep Dive into Peptide Science(14:37 - 27:22)

• Dr. Seeds introduces Tesmorelin as his second top peptide of 2024
• Tesmorelin is a secretagogue that stimulates physiologic release of growth hormone
• Works to improve mitochondrial function, beta oxidation of fat, and electron transport chain efficiency
• Discussion of how secretagogues differ from synthetic growth hormone
• Natural growth hormone has over 100 isoforms with different functions vs single isoform in synthetic
• Synthetic growth hormone causes constant receptor stimulation (not physiologic) leading to premature cell senescence
• Natural growth hormone is pulsatile, not continuous
• Explanation that peptides work at physiologic levels to help cells make their own decisions

Top Peptide and Cellular Mechanisms(27:23 - 37:33)

• Dr. Seeds identifies Semax as his third top peptide for 2024
• Semax is a neuropeptide that helps patients handle stress differently
• Breaks into active fragments including a tuftsin-type molecule for immune modulation
• Works on brain-derived neurotrophic factor (BDNF) and is a GABA agonist
• Discussion shifts to future peptide innovations focusing on mitochondrial function
• Detailed explanation of mitochondrial fission (splitting) and fusion (combining)
• Mitofusion 2 identified as key regulator of Hypoxic Inducing Factor 1 Alpha (HIF-1α)
• HIF-1α modulation crucial for muscle building, especially in older adults
• Dr. Seeds reveals they're already working on modulating these pathways with current methods

Peptide Modulation and Research Direction(37:34 - 43:36)

• Clarification that 'modulation' is not simply increasing or decreasing a process
• Peptides are modulators that respond to cellular environment appropriately
• Dr. Seeds explains how certain peptides can promote processes in healthy cells but inhibit the same processes in cancer cells
• Discussion about homeostasis and returning cells to natural balance
• Matt and Maddie compliment Dr. Seeds on his clear communication during the episode
• Reference to SSRP (Seeds Scientific Research & Performance) events and presentations

Ask Me Anything Segment - Part 1(43:37 - 55:34)

• Question about peptide advancements for athletes and injury recovery
• Dr. Seeds notes the increasing awareness of peptides and other molecules for improving recovery
• Emphasizes that recovery involves complex processes requiring comprehensive plans
• Acknowledges the expertise of many trainers and strength coaches who understand cellular mechanisms
• Discussion about collaboration between healthcare providers and fitness professionals
• Question about AI and genomics in peptide discovery
• AI is revolutionizing peptide development by modeling how peptides interact with cells
• AI helping to design peptides that target specific pathways and cellular processes
• Dr. Seeds mentions peptides being developed to combat viruses like COVID-19

Aesthetics Question and Future Episodes(55:35 - 59:40)

• Final question about what med spas get wrong with skin rejuvenation
• Dr. Seeds emphasizes the need for an 'inside out' approach rather than just 'outside in'
• Notes that cellular efficiency is fundamental to aesthetic improvements
• Mentions their peptide therapy certification program covers aesthetics alongside other modalities
• Announcement that next episode will feature Jay Faruga, an elite health and mindset coach
• Team expresses excitement about future topics and the podcast's direction
• Encouragement for listeners to follow on YouTube and Instagram

00:47
Dr. William Seeds
Hello and welcome to another episode of Redox Revolution. Matt and Maddie are here with me today to kick off another episode specific to the peptide pulse. 

00:59
Matthew Seeds
So here for the peptide pulse, we are looking back at 2024 at the most life changing peptides, maybe some that were key to scientific discovery this year. It really is a little bit of a game of preference here, maybe based on how things went with your patients, maybe some key research you were reading, you might have some favorites. But we're going to ask you for your top three and. 

01:25
Dr. William Seeds
You can ask me for my top three peptides. 

01:28
Matthew Seeds
Ask you for your top three peptides and I might even ask Madison if we have time. 

01:32
Dr. William Seeds
I think 2024 has been a, from my viewpoint, has been just historical in this explosion of people wanting to know more about a specific peptide and that's a GLP1 receptor agonist. And I bring that to light here because we've been working with GLP1 agonists for over 10 years. We've been down this road of introducing the education of GLP1s and their relevance to cellular metabolism and cellular efficiency and cellular resilience and all of a sudden people want to start listening. 

02:18
Matthew Seeds
It. It's funny talking with the other docs at our SSRP events and we'll kind of, we'll have asides and we'll laugh like, oh, did you see that GLP1s just got approved for so and so cases? And it's like, oh yeah, you know, Dr. Sees was talking about that in 2018. Here's the approval. Finally. 

02:38
Madison Lepore
Same with patients too. They're like we talked about it in our consult where we're discussing the GLP ones are like, did you see the news release article where they're looking at this for cardiac and brain health? More like, did you read your follow up consult notes? Like Dr. 

02:52
Dr. William Seeds
Seed said that, wow, I'm feeling reinforced here with you guys are supporting me today. 

03:00
Madison Lepore
You look up on the right side of the bed. 

03:02
Dr. William Seeds
So here, this, this relates back to here is this all of a sudden now we have an opportunity to seize a moment to discuss. I think one of the, you know, insulin had its place in its role in changing medicine. Well, I made this prediction 10 years ago, well beyond 10 years ago, that GLP1s would change medicine, would change health. And, and that was just based on understanding the mechanisms of what's occurring with one natural peptide that you make that has an influence in so many areas of the body. The brain. Muscle, bone, kidney, liver. 

03:51
Madison Lepore
Pancreas mat. 

03:52
Dr. William Seeds
Pancreas mat. 

03:53
Matthew Seeds
This is going to be a recurring. 

03:54
Dr. William Seeds
Thing and it's awesome because I think what's even better is all the noise out there where people are. You know, it's always a hook to pull people in on saying something's bad or there's, you know, beware of this. And, and I think that's good because it raises people's awareness and it makes them question. And, and that's awesome because it gives us this great arena to dispel these messaging myths. Myths of. 

04:31
Dr. William Seeds
Yeah, great job of GLP1s and I think the, you know, it all relates back to our first episode on talking about the cell and how everything starts really with this amazing ability of the beta cell of the pancreas mat pancreas to sense energy as glucose, to take that energy and make cells want to pull it in and utilize that energy in metabolism, to start signaling other cells on opportunities of efficiency and at the same time to build resilience, to build its ability to control that environment of stress. And it's just so amazing if you understand that part and then realize that this GLP1 has incredible ramifications moving forward where we can give people the opportunity to make not just changes in their lives today, but actually epigenetic changes in their life. 

06:01
Dr. William Seeds
Meaning we can guide the cell back into a better state of health that where the genes have been telling the cell to do a certain job and do it right. Well, bad diet or bad sleep or stress or viral infection has influenced that cell to not produce that messaging. And that's a phenotypical change. Well, this one peptide is here to stay in its ability now for people to let us spread this message that there's so much more to how this improves efficiencies of the cell. 

06:44
Matthew Seeds
So if you were predicting that this is where GLP1s would be today, 10 years ago, where do you think GLP1s will be 10 years from now? 

06:53
Dr. William Seeds
Well, look at what's happened. That's a great question. Look at what's happened so far with GLP1s and the reiterations of making GLP1s even more efficient. We've got GLP1s as Ozempic, we've got GLP1 and a GIP, two peptides together as tirzepatide. And then you've got, which is Manjaro, right? And then you've got tripeptide, retatrutide which is GLP1 GIP and glucagon, which are three peptides. And why have those iterations continued? Because they're further efficiencies of how they're mimicking more the normal process of cell function when it's stressed by glucose. And what happens with this interaction of insulin, growth hormone, cortisol. It's this, it's this symphony of signaling. 

07:55
Dr. William Seeds
And as we get better at understanding these pathways that need to happen simultaneously, we're getting better at improving these efficiencies, getting better at what this does to influence that cell resistance and using it at lower doses to influence normal cellular processes that we never had the ability to do before. And, and so in 10 years, where are we going to be? We're going to be at a place I, I believe that is again, not, there's not one answer. We're going to be at a place where we're going to be working. And I think we're already doing this where we realize that, okay, we're working on efficiencies with this GLP1 of the beta cell and we're doing everything to improve beta cell mass, beta cell resilience, and that's huge. 

08:56
Dr. William Seeds
And that beta cell can withstand stress as it has to produce more insulin or less insulin depending on the stressor. But then we're going to be doing things where we're working on the metabolism aspect of the mitochondria of controlling oxidative stress in that cell to calm that activity. And then we're also going to be working on the epigenetics of that cell by controlling methylation or acetylation of histones, which we're all, which by the way, we're already doing because we know these pathways, we know how to hit these different areas. But that's going to be the mainstay, I believe, in how we have a multi stemmed approach to ensuring the process of changing the entire playing field for that patient. 

09:55
Dr. William Seeds
And that's going to be more accepted as a process with these GLP1s and other aspects of what we do to work on metabolism and what we do to work on epigenetics. 

10:09
Madison Lepore
I do think it's important to mention too, each new iteration of the GLP1 becomes more efficient, but it also helps the patients tolerate it better. So with from the semi glutide to tirzepatide, adding that GIP help to decrease the nausea that they were getting. And then with the new retatrutide with the glucagon, it helps decrease the fatigue that patients can get when your metabolism changes. 

10:33
Matthew Seeds
So from the science and the innovation point of view, it seems like everything is still going up and up. But as somebody who works with these patients every day, how has it been riding the roller coaster of affordability and accessibility? Because, you know, in these early days when you guys were treating patients with GLP1s, it's pretty simple. You get em from your trusted compounding pharmacies and obviously in future episodes we'll dive into the complexities of compounded peptides versus research peptides and so forth. But as these bigger players have come in and yes, they've helped be a bellwether of the space to push peptide awareness. But the wegovis, the Ozempics, the Manjaros, what's that been like from the logistics and fulfillment point of view, pricing and affordability, and especially kind of an attack on compounding pharmacies? 

11:27
Madison Lepore
It's actually been, I think, eye opening for patients because compounding pharmacies were able to get these peptides for patients cheaper than they would get with insurance through the pharmacy. So that's what patients have actually wanted to come to us, even if their insurance would cover it because they're like, I'm still paying 16 or $1200 out of pocket with my insurance coverage on this prescription. So that actually hasn't really been an issue for us. 

12:00
Dr. William Seeds
And I think, and also part of our job is showing patients that as these efficiencies improve, we work with these higher level GLP1s, G I PS glucagon, we're actually able to use lower doses because they're more efficient. So in fact we're using lower doses, we're saving our patients more money in the respect of treating a problem. That, that's pretty incredible. If, if you can do something like that when, you know, as time goes on and these things get more sophisticated, they typically cost more, well, we can actually reduce the Cost because we know how to use it appropriately in actually the lower dosing. And you hear, you know, people out there talking about all this microdosing bullshit. This has been going on for we, for Liraglutide was a peptide that was used daily and that was one of the original peptides that be. 

13:08
Dr. William Seeds
After exenatide that were utilizing on a daily basis we learned how to work on metabolism, improve metabolism and then bring the dosing down into smaller doses where we could continue to stimulate other pathways and things that were focused on. And, and that's not, that was an art. That was a process of understanding what worked for the patient because we always have to do that individually. And, and then it, and then you have now, you know, these weekly GLP1s that change. It changed everything because it was once a week. And that became a compliance thing where people could do it easier, more people could enter the space because it was something they felt they could do and it had a better, it did have better effects on A1Cs and, and improving even more weight loss. But don't disrespect. 

14:06
Dr. William Seeds
Liraglutide was an amazing GLP one and still is an amazing one that we can talk about at some point. But were doing things with low dosing 10 years, I mean a long time ago and now all of a sudden everybody's like this expert of a we low dose and this is the only way to do it. It's like I shake my head and say no, it's not. I mean you got to know why you're using these. There are some people that start out in this journey that have no business being started in low doses. It's all individualized. And that's a discussion and that's an art. And I, I just want people to understand that there's real science here that should, that needs to be comprehended and understood and I'll leave it at that. 

14:57
Matthew Seeds
The point you make about the, sometimes the insurance pricing being even a little bit higher, that's something that I'm trying to follow a little closely is those third order effects from a systemic point of view because you're starting to see from a state governance level, the one I can think of the most is if you've seen the interview with the governor of North Carolina. I mean states budgets are getting hamstrung by all of a sudden when these GLP1s are getting approved for different use cases now they're being qualified under insurance and now these budgets are going down way faster than these states budgeted for. So it'll be interesting to see the kind of political pressure that gets put on some of these larger companies who try to maybe corner the market a little bit. 

15:45
Matthew Seeds
So there will not only be this upward pressure from everybody who wants these peptides to be more accessible, but I think we're also, at least in the future, going to start to see some downward pressure as well. 

15:56
Dr. William Seeds
Well, I think it's also been just a, I can't say enough for all of this to bring to light all the other aspects of peptides in their role in playing part of this journey of improving health and improving cellular maintenance and all the things we're discussing. It's been awesome to bring the light on this process. 

16:23
Matthew Seeds
And even though insulin, as you say, was the first GLP1s are essentially kind of paving the way, they're the trailblazer for this new age of medicine. And maybe it's just working the kinks out of the system for the rest of them to follow up. And I think that's a good place to jump right into what would be your second peptide of 2024. 

16:44
Dr. William Seeds
So, okay, so for 2024, I'm picking three. I mentioned the GLP one. So let's stay on this course of, of where I look at improving beta cell mass, making beta cell function, right? Working on resilience of how that works. Without getting into the mechanisms, what's my next step? My next step or my combined step is, okay, let's work on the metabolism and mitochondrial health. So that gets me to the process of what do we have available and what's been this incredible research that's been around for a while that now all of a sudden everybody's paying attention to. And that's the use of peptides that stimulate a physiologic release of growth hormone. 

17:42
Dr. William Seeds
And I want to emphasize how important this is, that this is physiologic because what is, what are we doing with that process essentially in the cell is we're making a part of that efficiency. We're, we're trying to work on the, that redox oxidative stress in the cell of that beta cell in the pancreas, right? Where we've done all the job with GLP1, now we're doing something to make that environment better, right? So this glp, this, I'm sorry, this secretag meaning a peptide to influence the anterior pituitary to release physiologic growth hormone that has so many downstream effects on all of your hormones, on your thymus for immune system, on actually metabolism in encouraging better beta oxidation of fat and improving the electron transport of the cell, which means efficiencies of producing ATP and NAD to manipulate. 

18:52
Dr. William Seeds
So the mitochondria has better control of the, its own antioxidant system. And, and you say, okay, I've got this beta cell that's working on controlling insulin, that's working on the food I eat, that there's hyperglycemia after I eat, that puts a stress on the beta cell. How can I help that stress? Well, the GLP1s do that. And then we're also now working on metabolism and improving that mitochondrial function and efficiencies of the cell to calm down that stress. That's amazing. And at the same time we're doing things to work not just on catabolism, but on anabolism, meaning rebuilding. And that is all about improving cell resilience, cellular strength, cellular cytoprotection. So it's very cool. So we're doing, we're taking these steps with this secretagogue that is also producing something called IGF1. And IGF1 plays in a tremendous role in working on cell resilience. 

20:03
Dr. William Seeds
Cytoprotection has so many areas of muscle rebuilding, brain health. Just incredible places we could go here and discussion of how important that is to, in a general scheme. And, and so that peptide I would say would be to just relate it to the literature and what it's done in the world for AIDS patients and helping them become more efficient because they develop adiposity around their adipose fat tissue around organs. And that's where all the research came from. And we learned that the gene regulation of these things called cytochromes. And I'll back off after this. I just think it's so fascinating because the research is deep on how we improve. We actually change the gene activation of something that's been dampened because of disease and viral infection, where we can upregulate that again to produce energy to make that mitochondria do its thing. 

21:13
Dr. William Seeds
So here we are with Tesmorellin. That is an incredible peptide to bring back metabolism in conjunction with where we're working with something else like a GLP one. And then we could go to the next step of. Okay, I, I could talk about that next step of epigenetic regulation with some peptides, but I'm gonna hold that off until we Talk about some other things moving down the road. But let's just talk about that experience and working with this patient. Let's say that I'm trying to improve all these parameters and you know, we see healthy people, we see people that have illnesses, we see people that are all very anxious to improve their health. 

22:09
Dr. William Seeds
And one thing that I don't, that I think we need to pay more attention to as practitioners is, and we become better at this is, okay, why are these people all getting into problems that are disease states or why is the cell not working efficiently as you get older? You know, what are those things influencing? Well, one of them is stressful. One of them is this unbelievable process of stress that we have no capability I think right now of truly understanding the significance of that. Well, stress we do know through molecular mechanisms they cause these damage associated molecular patterns that are real signaling agents that affect inflammation, that affects how the body responds to stress and actually causes low grade inflammatory states and leads to a lot of problems. 

23:09
Dr. William Seeds
Well, we have realized that all, you know, even like Jacques who was here with us in our other episode, Jock, you know, all these people don't realize they have this stress component. Well, this gets me to my third peptide called cell, which is a neuropeptide that I think is one of the most powerful peptides I use in my armatarium of trying to help people make some changes to get them to realize that we can make a difference. And why do I say that? Because this is a peptide that has that when it's when peptides are fragmented sometimes to have active biological fragments that do different things in cell signaling and in particular cell ink. 

24:04
Dr. William Seeds
It breaks off into a, what's called like a tuftsin type of molecule which is an immune modulating type of peptide that starts this process of helping us with the immune foundation. And I'll just say that in the brain that's a very important thing. But the other thing it does is it works on brain derived neurotropic factor and something else called gaba. It's a GABA agonist. All I'm talking about here is when you know all the things that these peptides do and you know these pathways, this peptide gives the patient the opportunity to, to handle stress in a different way. And some people, it's very obvious and they understand, they discuss it with you. Some people, you have to take them through the steps and have them recall their life for the last couple weeks and then they're like, oh my gosh, wow. 

25:00
Dr. William Seeds
You know, something's changed. Those are big steps. That's a big step for me to get this process working. So I, I know that I could say so much more. And we'll go into a whole spiel about this one and all of these peptides. But for the three right now, if you're going to ask me my three top ones, I'm going to say cell. Like I'm going to say a GLP1 and that means GLP1, G I P and Google. 

25:32
Matthew Seeds
It's a broad category, but we'll allow it. 

25:33
Dr. William Seeds
And, and the secretagog like tesmorellon. 

25:40
Madison Lepore
I do think it's important to. You're not recommending synthetic growth hormone? 

25:45
Dr. William Seeds
No. Well, so that's a great point. You know that. Not that. So synthetic growth hormone. If, if I could just make a generalized statement. When your brain produces growth hormone, there are over a hundred different isoforms of growth hormone that are released. What I mean by isoform is there are different forms of growth hormone that have different functions. We, you know, this is something that is very. You start to learn these things in cellular medicine that there are many stages of a hormone or peptide that are isoforms other types of the same molecule, but have slight changes that make a difference. So imagine that there's. So imagine growth hormone is this master hormone, but it's a peptide that. That has an effect on. Its job is to protect the cell, basically. 

26:40
Dr. William Seeds
Okay, so it has a stressor and a signal goes to the brain and depending on the stressor. Is it an injury? Is it a viral infection? Is it. Well, different isoforms of growth hormone are released to activate pathways to make changes. Well, synthetic growth hormone is one isoform out of a hundred. It's a repair growth hormone. So number one, why would you want to take something like that when you can influence the brain to do what it's supposed to do? Right. This is the brilliance of the cell. So number one. Number two is growth hormone is meant to be cycled. It. It's. It's not a constant bleed. 

27:23
Madison Lepore
It's pulse. 

27:24
Dr. William Seeds
It's pulse. Thank you. And. And synthetic growth hormone is a constant bleed. That means the receptor's being hit by growth hormone 24,7. That's not physiologic. That's wrong. And this is where we get into things we already know and have been studied that growth hormone leads to premature senescence of cells. And what is that? That's a bad thing. Senescence is a bad thing. And that's why you see all these Problems with people that have been on long term growth hormone, even in low doses, you see kidney issues, loss of glomerular filtration. When you see all, you see cardiac problems, you see a lot of issues. 

28:05
Dr. William Seeds
And it's all related, unfortunately to some methods that were meant to be good and were on the right track, but just didn't realize that synthetically, you know, again, this is like you're, you're introducing something exogenously that the body is not ready for 24 7. So that's my, those are my. I could, I could go into greater detail with that and how that interaction is, you know, from our standpoint for molecular medicine, that's understanding the tumor suppressor transcription factor p53, IGF1LR and the SIRT gene and how they work together to stop senescence and then how that influence either too much or too little can cause premature senescence. And it's been proven. So that's my. Thank you for bringing that up. Because what peptides, what's their focus? 

29:04
Dr. William Seeds
Their focus is to do things at a physiologic level or to get to a state of, where you can eventually be at a physiologic level to benefit the cell to make its own decisions. 

29:16
Madison Lepore
And it's all endogenous, not exogenous. 

29:19
Dr. William Seeds
Yeah, endogenous, meaning the body's producing it and it's not something we're giving that. The cell's like, well, what is this? And I, I think you know, it's, I think it's one of those things like what was that were talking about? Well, I think it's, I think the focus should be really like, gosh, that a hundred different isoforms of growth hormone for different aspects of that make, that sells itself. Right. 

29:50
Matthew Seeds
From a 2025 perspective. 

29:53
Dr. William Seeds
Whoa. 

29:54
Matthew Seeds
We've talked about GOP ones at nauseam, but the latter two that you mentioned, what are some of the innovations or maybe some research you're waiting for to maybe validate some of the things that you've been seeing and you've been thinking about. 

30:06
Dr. William Seeds
This is getting exciting. How do I go into this? So, so this gets into the mitochondria and this gets into more detail on, you know, we're finding that the issues of the cell are so linked to mitochondria and not just its function as a making energy, but its function as a cell signaling agent and how powerful it is the powerhouse of the cell. There you go. And, and what an influence that has on the in. In metabolism and also the influence it has on determining the phenotype of the cell. What I said, how stressors change the phenotype and so forth. And this gets into, even diving deeper into things on how the mitochondria to keep the quality control of the mitochondria to make sure that we're. The mitochondria is always. You're always regenerating new mitochondria. 

31:19
Dr. William Seeds
You're always making more to adapt to stress and to be productive. And there are these terms like fission and fusion of mitochondria. And this goes beyond my topic which means cleaning up mitochondria. So what I'm trying to get to is there are certain transcription factors and proteins that are based on. More on. On fusion of good mitochondria to be more powerful. And this is where the research. So fission can be a bad thing. Fusion can be a good thing. When things go bad in a cell, in a mitochondria, there's too much fission. That's cancer, that's immune problems. I mean I'm trying to break it down to some basics, but there's too much fission of fission, meaning the splitting of the mitochondria to try to disperse all the bad stuff into two different mitochondria and they're not as good. 

32:18
Dr. William Seeds
Fusion is putting two good mitochondria together to be even more powerful. Well, there are factors that are called Mito Fusion 1, Mito Fusion 2 and OPA 1 that are these transcription factors that work on building fusion. Well in particular there's Mitofusion 2 that plays a significant role in controlling something called Hypoxic Inducing Factor 1 Alpha. Hypoxic Inducing Factor 1 Alpha. If I just told you today has everything to do with how we can do a better job training and getting stronger and getting more muscle density or more muscle mass as we get older. And that hypoxic inducing factor has everything to do with cancer and all these bad things. And we are in a place right now of where we're understanding now that we are having the ability to control hypoxic modulate. I should say this Hypoxic Inducing Factor 1 Alpha. And why I'm. 

33:34
Dr. William Seeds
Why I'm so excited about this is because we're doing things to work on that right now. And I can work around but as mol as. As we get more specified peptides which are coming to specifically go at like enhancing mito fusion 2 if I can enhance my diffusion too, I can build muscle. You know, screw all this stuff about myostatin inhibitors and all. I'm getting down to the brass tacks of what really matters. And Mito Fusion 2 is a big deal and it changes my diffusion. 2 helps with the epigenetics also and it helps with, there are other things that happen if you can control Hypoxic Inducing Factor 1 Alpha. Holy shit. 

34:20
Madison Lepore
You can have really supercharged powerhouses of the cell. 

34:23
Dr. William Seeds
Yes. And, and we have a, we have inroads into. 

34:28
Matthew Seeds
I turn your Michael. 

34:30
Dr. William Seeds
We have in, we have inroads into working in an area, an extremely difficult area of cancer where cancer cells are brilliant in how they overtake a cell and control the environment. And if we know how that happens and we have ways to direct specific peptides to control that modulation. Because what happens in older people here, let me just break this down. This is really cool. Older people, as they get older and they can't make muscle number one. It's because that hypoxic inducing factor is not degraded. It, it sits around longer. It you Hypoxic Inducing Factor 1 Alpha is a good thing for a little bit, but if it's chronically being activated, it's not going to let you make muscle. It's just not going to happen. So we're already doing things. I have plenty of ways we can work on making that better. 

35:25
Dr. William Seeds
But more peptides are coming out to be directed to improving that modulation. That's phenomenal. I mean I, I, I can't tell you how exciting this is to know when you know these pathways and you know how specified we're getting in and making these peptides like more, you know, not linear but cyclic, which is a little more difficult to do it. And that makes the peptide more resilient to break down. We're making peptides more their ability to transport into the brain, easier to transport into the cell to bring cargo with them. 

36:07
Dr. William Seeds
I mean this world is exploding with this knowledge of where all these different peptides and I'm going to get into every episode, I'm telling you, we're filling this vault of information over the years now with things that are going to blow your mind with what's happening right now with where we're going in, being able to efficiently work with mimicking how a cell should work or giving that cell the ability to do those things. So isn't that fascinating? If you know how something goes bad. 

36:40
Madison Lepore
Make it good. 

36:41
Dr. William Seeds
Make it good. Make it, do it well in it. And I just gave you, I, I mean if I sat down here with where the future of cancer research is, or the future of muscle in for sarcopenia, but more importantly for those patients with Duchenne's muscular dystrophy, spinal muscular atrophy, all these terrible things that people have to deal with, and we're this close to working on improving that. I mean, that is just phenomenal and exciting. And it just drives this passion for me to want to know more, because we know it. We're. And we're getting closer to where these things can make a difference. 

37:19
Matthew Seeds
You're talking about workarounds that you're having to do at the moment, and you're talking about some of these future peptides that you're researching. And part of me wants to ask you about that, to dive into it, but another part of me thinks that might be a topic for a future episode. 

37:32
Dr. William Seeds
Yeah, well, there. There are. Because we are doing it right now. We can. So if you said, Dr. Seeds, are you manipulating. Are you helping in modulating mitofusion 2 right now? I'd say, hell, yeah. Are you helping in modulating Mitofusion 1 right now? I'd say, absolutely. Are you modulating Opal1? Absolutely. Are you modulating Drp1, which is the fission. You should go the other way right now and say, Dr. Seas, I think that's great. You're working on all this cool stuff to make the cells stronger. But what are you doing about those disease states where this cell. Where the mitochondria is in this fission state? And we know fission is the key again, to cancer, to sarcopenia, osteopenia, all these disease states. How can you improve fission? Are you working on that right now? 

38:25
Dr. William Seeds
I'd say, hell, yeah, we're working because that's understanding the DRP one, which is. Which are these proteins that, like, sit on the outer membrane, inner membrane, and it's just knowing how. Ooh, sorry. I get excited. It's knowing how it all works. Right? 

38:42
Matthew Seeds
Yeah. 

38:43
Dr. William Seeds
And I mean, that takes us right to. 

38:46
Madison Lepore
I think you should maybe define what modulating is, because you just used it a lot of times. 

38:51
Dr. William Seeds
So modulation. And here's a misconception. Yes, this is a misconception. 

38:58
Madison Lepore
It's not revving up. 

38:59
Dr. William Seeds
Right. It's a misconception. When you hear people talk in social media or this world of talking about these peptides and say, this peptide does this, and it creates this situation of, like, angiogenesis and proliferation. And we know those can be bad things for cancer and bad things in certain situations. Well, the cell know that. That that peptide is a Modulator, meaning it's in vi. It depends on the environment it's in. In it can encourage angiogenesis and encourage proliferation in repair and recovery. But let's say in cancer, it actually turns it off. It doesn't activate that process. That's brilliant. That's again the cell with its brilliance in using and modulating these. The. And a GLP one's a modulator. Oops, I gave away something here that's going to be in a future episode. Modulation is how people should think about these peptides and homeostasis. 

40:10
Madison Lepore
It's not revving up or revving down. It's just bringing back the homeostasis of the cell and what the cell wants. 

40:17
Dr. William Seeds
Redox. 

40:19
Madison Lepore
Yes. 

40:19
Matthew Seeds
I gotta say, from anybody who has listened to him talk over the years, the past and I. I might regret saying this later because we already talked them up so much in the first 10 minutes, but the last 20 minutes or so are some of the most organized and cognizant thoughts that you've put in a row, maybe ever. I didn't see you get lost down any rabbit holes. We said from the beginning we're here to be your guardrails. And you just crushed through that on your own. 

40:52
Dr. William Seeds
Why wouldn't I? 

40:53
Madison Lepore
Because you usually tend to go down rabbit holes. 

40:55
Matthew Seeds
You get so excited and go on these like side quests and everything. And that was. 

40:59
Madison Lepore
You kept. 

41:00
Matthew Seeds
That was pretty incredible. That was gold. And I think. I think what most people need to understand is the reason that's so incredible is because he's never reading off a teleprompter. These things aren't pre baked. He didn't even read this script for the episode today. 

41:17
Dr. William Seeds
He. 

41:17
Matthew Seeds
You're just jumping into it. 

41:18
Madison Lepore
Nor will he read any scripts for future episodes. 

41:21
Matthew Seeds
No, no, he never will. That's why we're here. 

41:25
Dr. William Seeds
Well, that goes back to the ssrp. When you guys. When you guys want me to make slides and you guys want me to follow slides and that was the biggest tug and pole. 

41:38
Matthew Seeds
Oh yeah. 

41:38
Madison Lepore
We're about an hour 45 minutes into the presentation and still on the tight on slide one. 

41:43
Dr. William Seeds
Yeah, but that's authentic. I want people to. I mean, I get excited because I let people participate in the audience. I let people bring up questions. The slides are there. You can always go back to the slides. I just make those for CME stuff. Or just so you have a knowledge base to go back to. My job is to make you think. My job is to provoke you to want to know more, to let people ask Questions. Yeah. 

42:09
Matthew Seeds
And that authenticity is the key to it. And this actually brings it to the perfect time to jump right into our ama, our ask me anything portion of the show. And you know, if you want to click on the link in the show notes below, you can submit a question too to potentially get answered in a future episode. But we will use some of the ones that we've already gotten so far. The first one I actually kind of want to tap into here. Should be good because of your history as an orthopedic surgeon, sports medicine specialist. What have been the biggest advancements in peptide therapies from athletes and for those recovering from injuries? 

42:49
Dr. William Seeds
That has been, that's kind of how I got my start actually in this world of. And that's why I went into orthopedics. That's what orthopedics was, an avenue for me to utilize my, I didn't realize they would be skills, but to utilize my knowledge to work on an area of repair, recovery from surgery from injury. And I, I think the biggest change has been that athletes and not just professional and collegiate, but just anybody's an athlete. Right? Anybody that works out or trains can be an athlete. And I kind of look at it all the same is that there are answers out there to enhance repair and recovery. And why is that so important? And why do I, why am I so focused on repair and recovery? 

43:55
Dr. William Seeds
Repair and recovery of an injury is all about again getting back to the basics of metabolism and immunity and making them work for enhancing repair. And, and so I think it's just been an awareness that there are peptides and other small molecules and, and so forth that work to improve that process. And that it isn't just one answer, that it is a complex process of building a plan and seeing it through. And I think that's been the most incredible thing right now to see that information out there and the fact that now the trainers and the strength coaches are harnessing that information, that they're all over it. And, and there's some, these guys are talented, they're seeking this information. I mean, let me put some, let me put some people on notice here. 

45:14
Dr. William Seeds
We as healthcare providers need to understand that when somebody comes in with information and they're discussing some things with you that you may not know is out there and what's going on in particular this world of peptides and recovery repair. There are some really well knowledged trainers and strength trainers out there, strength coaches that totally understand the Molecular mechanisms of the cell, understand nutrition, understand the balance of sleep, understand all these things we're talking about. And I'm going to tell you what, they know it really well and that's so incredible and empowering that patients have that access with their trainers, with their strength coaches, because they're actually, they've made this a better space for us to do our job because people are accepting. There isn't one answer. It's, it's a multitude of processes and I, I think. And that's education, right? 

46:16
Dr. William Seeds
And that's what the SSRP is about. 

46:19
Matthew Seeds
I was about to say we get to work with so many of them at the ssrp, and it's enlightening to see just the level of energy they bring to the space because, you know, I, I don't feel like I'm speaking out of turn here. I, it seems like they were kind of getting held out of things for a long time and eventually, you know, the dam overflowed and they're like, screw that. We want to know more. We want to be a part of this. And it's been awesome that, that's the momentum that's been carried over. 

46:49
Dr. William Seeds
Well, and they bring, so they bring so much value. Okay. Because they ask questions that sometimes we don't ask as healthcare providers or a patient doesn't ask. They, they see a process, but they may not know it like a healthcare provider or a physician. They may not see all the intricate details and they may think some things work together because this is what they're supposed to do, but they provide that discussion of starting that journey and understanding how we can work on improving recovery and repair and coming together and collaborating to be smarter. And look at, just for instance, look at our strength people, our trainers that have spent the time to understand more of what we're doing. Look at, look at what they've been able to do. It's, it's pretty incredible, actually. 

47:51
Matthew Seeds
Well, and this is the reason that we're going to have a whole dedicated strength portion at the Peptide World Congress. So that's going to be fun. But honestly, the last point I want to make on this, and it's, it goes back to one of your original points that you make over and over. You want to listen to somebody who's on the front lines, who's seeing patients, right? If you're comparing people in the strength training arena to providers, as a provider just kind of the way the system works, you get to see a patient, what, maybe four times a year? Three or four, yeah. Most of these trainers, they're on the front lines with their clients every week, if not every day. So they're seeing the results of their regiments and the things that they're doing with their clientele moment to moment. 

48:39
Matthew Seeds
So they're almost getting a more realistic and more upfront point of view than almost anybody can. 

48:43
Madison Lepore
And to add onto that, patients find that so valuable because their trainers are noticing the difference and the improvement in their strength and their improvement in their recovery. So it's also just another form of reinforcement for the patient that like, okay, yes, these things I'm doing are working and I am benefiting from them. 

49:06
Matthew Seeds
So. Second question for the Ask me anything that we've gotten. How has technology like AI or genomics influenced peptide discovery and how do you think it might continue to influence it? 

49:18
Dr. William Seeds
It's changing the world. It's phenomenal because we can do. They're already, that's how the using AI and in building models of building peptides and their potential of how they can interact with the cell is the future of, of these newer peptides that are coming out. That it's all about that right now. And that is phenomenal. I'm, I'm a big supporter and you know, what we do, working with, how we're learning, I, that's where my space is as I'm out there learning what everybody's doing and helping and maybe collaborating a little bit from the physician side with the research side of, hey, this is where we need to look. This is what, this is what I see as mechanisms or pathways that we should be focusing on. 

50:17
Dr. William Seeds
And, but you can, with AI, we can do so much more in building these peptides and actually playing out the potential of what that will influence in the cell. Not, you know, it's rudimentary right now, but it's fascinating to see it's going to keep developing and how it's almost like that AI is a cell that we're introducing a peptide to and we're seeing how that changes a cell. Well, that's where AI is going with this is you're getting a duplicate of your cell of how you can conform a peptide to have an influence on a pathway and build a peptide that will do that signaling and will have those conformational changes of a receptor or whatever you're looking for. It, it just, it's, it's so mind blowing when you think about all the different areas this Enters into. 

51:23
Dr. William Seeds
Of different peptides and different properties of peptides and where you can go with that with the AI and in development. And it's happening. It's how we have. It's. It's how we have the. I don't know if people are aware of that, but we have now clearly. What's that? 

51:46
Madison Lepore
The clearly scan? 

51:47
Dr. William Seeds
No, no, no. We have peptides that have been. They're a little behind with the process of utilizing AI and so forth. But looking at how we deal with viruses like Covid and having specific peptides to work against the activation of a RNA virus or a DNA virus, instead of using messenger rna, we can get even more precise and do things with peptides to influence that the virus itself and its entry into a cell or and so forth. So it's fascinating where this is going. 

52:23
Matthew Seeds
Speaking of entering into a cell, that's actually kind of a good segue into our last question. So there's a lot of med spas out there, a lot of people who. Their primary focus is aesthetics and skincare. When it comes to skin rejuvenation, anti aging. What is one thing that a lot of these clinics get wrong? 

52:53
Dr. William Seeds
So I think you've already started to hear this. I'm going to call it a revolution in thinking because these are people that have been that I, I hope that I've influenced in understanding that to improve the aspects of, let's say, working on aesthetics of let. Like we're talking about the face and we're talking about the complexities of collagen and elastin and cells like keratinocytes and melanocytes and fibroblasts and their influence they have in keeping the hydration of the skin, the connective aspect, the connective tissue of collagen, the elasticity, all these things are crucial in maintaining structure. And it's always been this outside in approach of rub this on, do this micro abrasion. It's always outside in. Well, you're starting to hear. And this I'm going to tell you we this started. 

54:14
Dr. William Seeds
I want to own this because the people talking about are the people that trained for or were came to me. You gotta work inside out, right? It only makes sense. You've got. But what if you combine inside outside in. And what do I mean by inside out? Well, doesn't it make sense with the things I've been talking about if we're going to make cells efficient? 

54:37
Matthew Seeds
Starts with the cell. 

54:38
Dr. William Seeds
It starts with the cell. That's where the revolution is. Is going to be seen. And it's already happening of where these companies are saying, hey, we do this too. You got to take this orally. And that's sometimes where they get it wrong because that doesn't work. Or. I mean, I, we'll. We're going to break that all down because I'd love to go into that space full tilt, but I want people. I, I wish people would recognize and give us a little credit that the. We're help. We've helped them get to that stage of understanding that you gotta work from the inside out and then you can do some incredible things. And that's why we're not caught up at Redox Medical. We're not caught up in all this crazy. I shouldn't say crazy. All these devices you can use to make yourself look great. 

55:32
Dr. William Seeds
It's, it's about. We're about the science. Let's work on inside and let's combine some things that we know are helpful from the outside in. And let's not gouge the out of you and have you come back 50 million times to do something. And let's make it work and let's make it right. And I'm not saying I'm not. And that's. You know, Matt, you should emphasize we have plenty of people that run these med spots that do it like we're talking about. 

56:04
Matthew Seeds
Of course. 

56:04
Dr. William Seeds
Because they train with us and they're kicking butt because they're sending the right message. That's what I'm trying to. To iterate here is that. And they're proud to represent us and. 

56:18
Matthew Seeds
And that's why it's so crucial in our peptide therapy certification program. You're going through those 10 modalities? Yes. One of them is aesthetics. And people sometimes ask, well, can I just get certified in aesthetics? No. You need to understand where all of these different areas are overlapping with each other. If you're going to do this. How does it affect you cardiovascularly? How does it affect you musculoskeletally? 

56:40
Dr. William Seeds
Well, well. And that's the area. Think of the impact these med spas and what we've heard back from our people that. That do that. Of how they've changed people's lives by just working on that. Right. Of just, hey, I'm actually participating in improving cell function. Oh, my gosh. Besides this patient feeling better about how they look. They're feeling better. Holy smokes. That's got to send some smoke signals somewhere. 

57:06
Matthew Seeds
Because if it all starts with the cell, it all not just going to improve looks. It's going to improve everything. 

57:12
Dr. William Seeds
Everything. 

57:12
Matthew Seeds
So we will go full tilt into that later, like you said, and we will continue to answer your questions as well. As a reminder, if you have anything you want to ask, just click the link in the show notes below. Thank you to everybody who submitted questions for. For this first Ask Me Anything session. It was pretty good. Once again. Didn't go down many rabbit holes. 

57:33
Madison Lepore
Why are yourself on the back? 

57:34
Dr. William Seeds
What. What do you think? What is that? 

57:36
Madison Lepore
If you're nervous because we're here, you feel the pressure? 

57:40
Matthew Seeds
Yeah, I think. I think we're getting to you. Well, keep your brain turned on if you can keep it on for at least another week, because next episode we will be joined by Jay Faruga, who is an elite head health and mindset coach, to find out his secrets for both peak performance and mentality. 

57:58
Madison Lepore
Can't wait. 

57:59
Dr. William Seeds
I'm looking forward to that because again, here's going to be a collaboration of. Of what we can do together in providing some, I think, some awesome insight to helping patients and. And in this pursuit of healthcare. 

58:16
Matthew Seeds
And it's always just nice to have the fourth chair full. 

58:19
Dr. William Seeds
It is nice to do that. You're right. I like that. Yeah, it adds. It adds to the redo of the room. Oh, we're out of balance. Look at that. Okay, good job. Thank you. Welcome. 

58:33
Matthew Seeds
All right, Mike, mic drop. Yeah, that's it. 

58:35
Dr. William Seeds
I like it. That's it. All right, well, thank you for being here on another episode of Redox Revolution. Matt. Matty. Thank you. I am so excited where this is going. I. I've had so much fun over the last four weeks. I. I've got hundreds of different ways we can go with this. I don't think it'll ever end. I. And I think this is just so. Thank you for letting me share my passion here and thank you for keeping the guardrails on me and trying to direct my messaging. 

59:11
Matthew Seeds
No, that was all you this time. You bowled a strike, so jump. 

59:14
Madison Lepore
You did great. 

59:15
Dr. William Seeds
Matt. 

59:16
Madison Lepore
Are you going to get him through the door? 

59:17
Matthew Seeds
No, he's. He just has to stay here till next week. It'll be fine. 

59:21
Dr. William Seeds
All right. Until later. Thank you. 

59:24
Matthew Seeds
Hey, it's the fourth episode. What are you doing if you're not already? YouTube, Instagram. Dr. William Seeds @ Redox Medical Group. Like, subscribe, engage. We'll see you next week. 

59:39
Dr. William Seeds
Sa.